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KMID : 1234420100380030227
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Korean Journal of Microbiololgy and Biotechnology
2010 Volume.38 No. 3 p.227 ~ p.234
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Streptomyces Cytochrome P450 and Electron Transport System
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Sohng Jae-Kyung
Oh Tae-Jin
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Abstract
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Institute of Biomolecule Reconstruction (iBR), Department of Pharmaceutical Engineering, Sun Moon University, Asan 336-708, Korea ? Cytochrome P450 enzymes which require the supply of electrons from NAD(P)H have a great biotechnological impact as they catalyze valuable reactions on a vast variety of substrates. However, very limited biotechnological application has been reported so far due to their functional complexity, limited stability (instability) and, in most cases, low catalytic activity. In this present review, we introduce some possibilities for improving their defect by exploring electron transport system and substrate flexibility in field of Streptomyces cytochrome P450.
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KEYWORD
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Cytochrome P450, electron transport system, ferredoxin, ferredoxin reductase, NAD(P)H, Streptomyces
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